3HMX

Crystal structure of ustekinumab FAB/IL-12 complex

3HMX の概要

• エントリーDOI: 10.2210/pdb3hmx/pdb
• 分子名称: Interleukin-12 subunit beta, Interleukin-12 subunit alpha, USTEKINUMAB FAB LIGHT CHAIN, ... (6 entities in total)
• 機能のキーワード: ustekinumab, cnto1275, il-12, il-23, antibody, fab, monoclonal antibody, immune system, cytokine, disulfide bond, glycoprotein, immunoglobulin domain, secreted, growth factor, cytokine-mmune system complex, cytokine-immune system complex, cytokine/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106055.37

構造登録者

Luo, J. (登録日: 2009-05-29, 公開日: 2010-06-09, 最終更新日: 2020-07-29)

• 主引用文献: Luo, J.,Wu, S.J.,Lacy, E.R.,Orlovsky, Y.,Baker, A.,Teplyakov, A.,Obmolova, G.,Heavner, G.A.,Richter, H.T.,Benson, J.; Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.; J.Mol.Biol., 402:797-812, 2010; PubMed: 20691190; DOI: 10.1016/j.jmb.2010.07.046

実験手法

X-RAY DIFFRACTION (3 Å)