3HMP

Crystal structure of human Mps1 catalytic domain in complex with a quinazolin ligand Compound 4

Summary for 3HMP

Entry DOI	10.2210/pdb3hmp/pdb
Related	2ZMC 2ZMD 3HMN 3HMO
Descriptor	Dual specificity protein kinase TTK, 7-chloro-N-(cyclopropylmethyl)quinazolin-4-amine, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ... (7 entities in total)
Functional Keywords	mps1, ttk, cx4, kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, tyrosine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40193.21
Authors	Chu, M.L.H.,Chavas, L.M.G.,Williams, D.H.,Tabernero, L.,Eyers, P.A. (deposition date: 2009-05-29, release date: 2010-02-02, Last modification date: 2023-09-06)
Primary citation	Chu, M.L.,Lang, Z.,Chavas, L.M.,Neres, J.,Fedorova, O.S.,Tabernero, L.,Cherry, M.,Williams, D.H.,Douglas, K.T.,Eyers, P.A. Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. Biochemistry, 49:1689-1701, 2010 Cited by PubMed: 20099905 DOI: 10.1021/bi901970c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation