Summary for 3HMM
Entry DOI | 10.2210/pdb3hmm/pdb |
Related | 3GXL |
Descriptor | TGF-beta receptor type-1, 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine (3 entities in total) |
Functional Keywords | tgf-beta, alk5, kinase, inhibitor, quinazoline, aortic aneurysm, atp-binding, craniosynostosis, disease mutation, disulfide bond, glycoprotein, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein polymorphism, receptor, serine/threonine-protein kinase, transferase, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P36897 |
Total number of polymer chains | 1 |
Total formula weight | 35037.35 |
Authors | Smith, W.,Janson, C. (deposition date: 2009-05-29, release date: 2009-06-23, Last modification date: 2023-11-01) |
Primary citation | Gellibert, F.,Fouchet, M.-H.,Nguyen, V.-L.,Wang, R.,Krysa, G.,de Gouville, A.-C.,Huet, S.,Dodic, N. Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors Bioorg.Med.Chem.Lett., 19:2277-2281, 2009 Cited by PubMed: 19285388DOI: 10.1016/j.bmcl.2009.02.087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report