3HMI

The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

Summary for 3HMI

• Entry DOI: 10.2210/pdb3hmi/pdb
• Related: 3GVU
• Descriptor: Tyrosine-protein kinase ABL2, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE (3 entities in total)
• Functional Keywords: tyrosine kinase, abl, abl2, abelson murine leukemia viral oncogene, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton: P42684
• Total number of polymer chains: 1
• Total formula weight: 33968.79

Authors

Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Allerston, C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-05-29, release date: 2009-07-07, Last modification date: 2023-11-01)

• Primary citation: Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Allerston, C.,von Delft, F.,Knapp, S.; The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE; To be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)