3HLJ

Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide

Summary for 3HLJ

Entry DOI	10.2210/pdb3hlj/pdb
Descriptor	Carbonic anhydrase 2, 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide, SODIUM ION, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, sulfonamide, thiadiazole, lyase, disease mutation, metal-binding
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29677.84
Authors	Grazulis, S.,Manakova, E.,Golovenko, D. (deposition date: 2009-05-27, release date: 2010-03-02, Last modification date: 2023-11-01)
Primary citation	Baranauskiene, L.,Hilvo, M.,Matuliene, J.,Golovenko, D.,Manakova, E.,Dudutiene, V.,Michailoviene, V.,Torresan, J.,Jachno, J.,Parkkila, S.,Maresca, A.,Supuran, C.T.,Grazulis, S.,Matulis, D. Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides J Enzyme Inhib Med Chem, 25:863-870, 2010 Cited by PubMed: 20166809 DOI: 10.3109/14756360903571685 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.44 Å)

Structure validation