3HL4

Crystal structure of a mammalian CTP:phosphocholine cytidylyltransferase with CDP-choline

3HL4 の概要

• エントリーDOI: 10.2210/pdb3hl4/pdb
• 分子名称: Choline-phosphate cytidylyltransferase A, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: cytidylyltransferase, rossmann fold, phospholipid synthesis, phosphatidylcholine, phosphocholine, ctp, cdp-choline, amphitropic protein, lipid metabolism, nucleotidyltransferase, phosphoprotein, transferase
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Cytoplasm, cytosol: P19836
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54975.05

構造登録者

Lee, J.,Paetzel, M.,Cornell, R.B. (登録日: 2009-05-26, 公開日: 2009-09-22, 最終更新日: 2024-02-21)

• 主引用文献: Lee, J.,Johnson, J.E.,Ding, Z.,Paetzel, M.,Cornell, R.B.; Crystal Structure of a mammalian CTP: Phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyl-transferase fold; J.Biol.Chem., 284:33535-33548, 2009; PubMed: 19783652; DOI: 10.1074/jbc.M109.053363

実験手法

X-RAY DIFFRACTION (2.2 Å)