3HKU

Human carbonic anhydrase II in complex with topiramate

3HKU の概要

• エントリーDOI: 10.2210/pdb3hku/pdb
• 関連するPDBエントリー: 3HKQ 3HKT
• 分子名称: Carbonic anhydrase 2, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase drug design, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29693.83

構造登録者

Paul, B.,Poulsen, S.-A.,Hofmann, A. (登録日: 2009-05-25, 公開日: 2009-10-13, 最終更新日: 2024-03-20)

• 主引用文献: Lopez, M.,Paul, B.,Hofmann, A.,Morizzi, J.,Wu, Q.K.,Charman, S.A.,Innocenti, A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.; S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.; J.Med.Chem., 52:6421-6432, 2009; PubMed: 19827837; DOI: 10.1021/jm900914e

実験手法

X-RAY DIFFRACTION (1.8 Å)