3HIV
Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue
Summary for 3HIV
Entry DOI | 10.2210/pdb3hiv/pdb |
Related | 3HIO 3HIQ 3HIS 3HIT 3HIW |
Descriptor | Vacuolar saporin, (2R,3R,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(3R,4R)-4-({[(S)-{[(2R,3R,4R,5R)-5-(2-amino-6-oxo-6,8-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl]oxy}(hydroxy)phosphoryl]oxy}methyl)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidin-3-yl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-methoxytetrahydrofuran-3-yl 3-hydroxypropyl hydrogen (S)-phosphate (3 entities in total) |
Functional Keywords | transition state, ribosome inactivating proteins, rips, hydrolase, plant defense, protein synthesis inhibitor, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saponaria officinalis (Common soapwort) |
Total number of polymer chains | 2 |
Total formula weight | 59775.18 |
Authors | Ho, M.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2009-05-20, release date: 2009-12-08, Last modification date: 2024-02-21) |
Primary citation | Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106:20276-20281, 2009 Cited by PubMed: 19920175DOI: 10.1073/pnas.0911606106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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