3HI5

Crystal structure of Fab fragment of AL-57

Summary for 3HI5

• Entry DOI: 10.2210/pdb3hi5/pdb
• Related: 3HI6
• Descriptor: Heavy chain of Fab fragment of AL-57 against alpha L I domain, light chain of Fab fragment of AL-57 against alpha L I domain (3 entities in total)
• Functional Keywords: fab fragment, ligand mimetic, integrin, i domain, cell adhesion, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 46781.93

Authors

Zhang, H.,Wang, J. (deposition date: 2009-05-18, release date: 2009-09-22, Last modification date: 2017-11-01)

• Primary citation: Zhang, H.,Liu, J.H.,Yang, W.,Springer, T.,Shimaoka, M.,Wang, J.H.; Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1.; Proc.Natl.Acad.Sci.USA, 106:18345-18350, 2009; PubMed: 19805116; DOI: 10.1073/pnas.0909301106

Experimental method

X-RAY DIFFRACTION (2.5 Å)