3HHK
HCV NS5b polymerase complex with a substituted benzothiadizine
Summary for 3HHK
Entry DOI | 10.2210/pdb3hhk/pdb |
Descriptor | HCV NS5 polymerase, 2-({(3R)-3-[(3S)-1-(3-methylbutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl]-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide (3 entities in total) |
Functional Keywords | ns5b, polymerase, hcv, inhhibitor, atp-binding, envelope protein, helicase, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus subtype 1b |
Cellular location | Virion : Q99AU2 |
Total number of polymer chains | 2 |
Total formula weight | 125842.18 |
Authors | Concha, N.O.,Singh, O. (deposition date: 2009-05-15, release date: 2009-09-08, Last modification date: 2024-02-21) |
Primary citation | Shaw, A.N.,Tedesco, R.,Bambal, R.,Chai, D.,Concha, N.O.,Darcy, M.G.,Dhanak, D.,Duffy, K.J.,Fitch, D.M.,Gates, A.,Johnston, V.K.,Keenan, R.M.,Lin-Goerke, J.,Liu, N.,Sarisky, R.T.,Wiggall, K.J.,Zimmerman, M.N. Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. Bioorg.Med.Chem.Lett., 19:4350-4353, 2009 Cited by PubMed: 19515564DOI: 10.1016/j.bmcl.2009.05.091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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