3HGN
Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography
Summary for 3HGN
Entry DOI | 10.2210/pdb3hgn/pdb |
Related | 3HGP |
Descriptor | Elastase-1, 4-[[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-pentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamoyl]benzoic acid, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | chymotrypsin family, hydrolase, serine protease, disulfide bond, metal-binding, protease, secreted, zymogen |
Biological source | Sus scrofa (Pig) |
Cellular location | Secreted: P00772 |
Total number of polymer chains | 1 |
Total formula weight | 26578.66 |
Authors | Tamada, T.,Kinoshita, T.,Kuroki, R.,Tada, T. (deposition date: 2009-05-14, release date: 2009-07-28, Last modification date: 2023-11-01) |
Primary citation | Tamada, T.,Kinoshita, T.,Kurihara, K.,Adachi, M.,Ohhara, T.,Imai, K.,Kuroki, R.,Tada, T. Combined High-Resolution Neutron and X-ray Analysis of Inhibited Elastase Confirms the Active-Site Oxyanion Hole but Rules against a Low-Barrier Hydrogen Bond J.Am.Chem.Soc., 131:11033-11040, 2009 Cited by PubMed: 19603802DOI: 10.1021/ja9028846 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (1.65 Å) X-RAY DIFFRACTION (1.201 Å) |
Structure validation
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