3HFG
Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Sulfonyl-piperazine Inhibitor
Summary for 3HFG
Entry DOI | 10.2210/pdb3hfg/pdb |
Related | 3H6K |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-{[3-(1H-1,2,4-triazol-1-yl)phenyl]sulfonyl}piperazine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, hsd1, nadp, inhibitor, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, polymorphism, signal-anchor, steroid metabolism, transmembrane |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845 |
Total number of polymer chains | 4 |
Total formula weight | 132198.94 |
Authors | Bard, J.,Svenson, K. (deposition date: 2009-05-11, release date: 2009-09-29, Last modification date: 2024-02-21) |
Primary citation | Wan, Z.K.,Chenail, E.,Xiang, J.,Li, H.Q.,Ipek, M.,Bard, J.,Svenson, K.,Mansour, T.S.,Xu, X.,Tian, X.,Suri, V.,Hahm, S.,Xing, Y.,Johnson, C.E.,Li, X.,Qadri, A.,Panza, D.,Perreault, M.,Tobin, J.F.,Saiah, E. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J.Med.Chem., 52:5449-5461, 2009 Cited by PubMed: 19673466DOI: 10.1021/jm900639u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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