3HFB

Crystal structure of human tryoptophan hydroxylase type 1 with LP-534193

3HFB の概要

• エントリーDOI: 10.2210/pdb3hfb/pdb
• 関連するPDBエントリー: 3HF6 3HF8
• 分子名称: Tryptophan 5-hydroxylase 1, FE (III) ION, 4-(5-{[(2'-methylbiphenyl-2-yl)methyl]amino}pyrazin-2-yl)-L-phenylalanine, ... (4 entities in total)
• 機能のキーワード: tryptophan hydroxylase type 1, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein, serotonin biosynthesis
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33782.28

構造登録者

Tari, L.W.,Swanson, R.V.,Hunter, M.J. (登録日: 2009-05-11, 公開日: 2010-04-21, 最終更新日: 2024-02-21)

• 主引用文献: Cianchetta, G.,Stouch, T.,Yu, W.,Shi, Z.C.,Tari, L.W.,Swanson, R.V.,Hunter, M.J.,Hoffman, I.D.,Liu, Q.; Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.; Curr Chem Genomics, 4:19-26, 2010; PubMed: 20556201; DOI: 10.2174/1875397301004010019

実験手法

X-RAY DIFFRACTION (1.92 Å)