3HF6
Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE
Summary for 3HF6
Entry DOI | 10.2210/pdb3hf6/pdb |
Descriptor | Tryptophan 5-hydroxylase 1, FE (III) ION, 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine, ... (4 entities in total) |
Functional Keywords | tryptophan 5-hydroxylase 1, alternative splicing, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein, serotonin biosynthesis |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33772.24 |
Authors | Tari, L.W.,Swanson, R.V.,Hunter, M.J. (deposition date: 2009-05-11, release date: 2009-11-24, Last modification date: 2024-02-21) |
Primary citation | Cianchetta, G.,Stouch, T.,Yu, W.,Shi, Z.-C.,Tari, L.W.,Swanson, R.V.,Hunter, M.J.,Hoffman, I.D.,Liu, Q. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis Curr Chem Genomics, 4:19-26, 2010 Cited by PubMed: 19631532DOI: 10.2174/1875397301004010019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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