3HB5

Binary and ternary crystal structures of a novel inhibitor of 17 beta-HSD type 1: a lead compound for breast cancer therapy

Summary for 3HB5

• Entry DOI: 10.2210/pdb3hb5/pdb
• Related: 3HB4
• Descriptor: Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[(9beta,14beta,16alpha,17alpha)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, ... (4 entities in total)
• Functional Keywords: 17beta-hsd1, cytoplasm, lipid synthesis, nadp, oxidoreductase, polymorphism, steroid biosynthesis
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14061
• Total number of polymer chains: 1
• Total formula weight: 36036.76

Authors

Mazumdar, M.,Lin, S.-X. (deposition date: 2009-05-04, release date: 2009-12-15, Last modification date: 2024-02-21)

• Primary citation: Mazumdar, M.,Fournier, D.,Zhu, D.W.,Cadot, C.,Poirier, D.,Lin, S.X.; Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.; Biochem.J., 424:357-366, 2009; PubMed: 19929851; DOI: 10.1042/BJ20091020

Experimental method

X-RAY DIFFRACTION (2 Å)