3HB4
17beta-hydroxysteroid dehydrogenase type1 complexed with E2B
Summary for 3HB4
Entry DOI | 10.2210/pdb3hb4/pdb |
Related | 3HB5 |
Descriptor | Estradiol 17-beta-dehydrogenase 1, 3-{[(9beta,14beta,16alpha,17alpha)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide (3 entities in total) |
Functional Keywords | 17betahsd1, cytoplasm, lipid synthesis, nadp, oxidoreductase, polymorphism, steroid biosynthesis |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14061 |
Total number of polymer chains | 1 |
Total formula weight | 35293.36 |
Authors | Mazumdar, M.,Fournier, D.,Zhu, D.-W.,Cadot, C.,Poirier, D.,Lin, S.-X. (deposition date: 2009-05-04, release date: 2009-12-15, Last modification date: 2024-02-21) |
Primary citation | Mazumdar, M.,Fournier, D.,Zhu, D.W.,Cadot, C.,Poirier, D.,Lin, S.X. Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy. Biochem.J., 424:357-366, 2009 Cited by PubMed: 19929851DOI: 10.1042/BJ20091020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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