3HA1

Alanine racemase from Bacillus Anthracis (Ames)

Summary for 3HA1

• Entry DOI: 10.2210/pdb3ha1/pdb
• Related: 1rcq 1sft 1xfc 2vd8
• Descriptor: Alanine racemase, ACETATE ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: alanine racemase, isomerase, plp, pyridoxal phosphate
• Biological source: Bacillus anthracis (anthrax,anthrax bacterium)
• Total number of polymer chains: 2
• Total formula weight: 90139.35

Authors

Counago, R.M.,Davlieva, M.,Strych, U.,Hill, R.E.,Krause, K.L. (deposition date: 2009-04-30, release date: 2009-09-15, Last modification date: 2023-11-22)

Primary citation

Counago, R.M.,Davlieva, M.,Strych, U.,Hill, R.E.,Krause, K.L.
Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames).
Bmc Struct.Biol., 9:53-53, 2009

PubMed Abstract: Bacillus anthracis is the causative agent of anthrax and a potential bioterrorism threat. Here we report the biochemical and structural characterization of B. anthracis (Ames) alanine racemase (AlrBax), an essential enzyme in prokaryotes and a target for antimicrobial drug development. We also compare the native AlrBax structure to a recently reported structure of the same enzyme obtained through reductive lysine methylation.

PubMed: 19695097
DOI: 10.1186/1472-6807-9-53

Experimental method

X-RAY DIFFRACTION (1.95 Å)