3H9R
Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin
Summary for 3H9R
Entry DOI | 10.2210/pdb3h9r/pdb |
Descriptor | Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, ... (6 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, atp-binding, disease mutation, glycoprotein, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, receptor, serine/threonine-protein kinase, transferase, transmembrane, isomerase, rotamase, isomerase-protein kinase complex, isomerase/protein kinase |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: Q04771 Cytoplasm: P62942 |
Total number of polymer chains | 2 |
Total formula weight | 50916.01 |
Authors | Chaikuad, A.,Alfano, I.,Shrestha, B.,Muniz, J.R.C.,Petrie, K.,Fedorov, O.,Phillips, C.,Bishop, S.,Mahajan, P.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2009-04-30, release date: 2009-06-02, Last modification date: 2023-09-06) |
Primary citation | Chaikuad, A.,Alfano, I.,Kerr, G.,Sanvitale, C.E.,Boergermann, J.H.,Triffitt, J.T.,von Delft, F.,Knapp, S.,Knaus, P.,Bullock, A.N. Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva. J.Biol.Chem., 287:36990-36998, 2012 Cited by PubMed: 22977237DOI: 10.1074/jbc.M112.365932 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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