3H9R
Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activin receptor type-1 | polymer | 330 | 37398.7 | 1 | UniProt (Q04771) Pfam (PF08515) Pfam (PF00069) | Homo sapiens (human) | Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, Activin receptor-like kinase 2, ALK-2, TGF-B superfamily receptor type I, TSR-I |
| 2 | B (B) | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 109 | 12054.8 | 1 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1A, FK506-binding protein 1A, FKBP-1A, Rotamase, Immunophilin FKBP12, 12 kDa FKBP, FKBP-12 |
| 3 | C (A) | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | non-polymer | 399.5 | 1 | Chemie (TAK) | |||
| 4 | D, E, F, G, H (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | I, J, K (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 263 | Chemie (HOH) |
Sequence modifications
A: 172 - 499 (UniProt: Q04771)
B: 1 - 108 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Ser 170 | - | expression tag |
| Met 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49453.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1462.5 | |
| All* | Total formula weight | 50916.0 |
