3H9O

Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9

3H9O の概要

• エントリーDOI: 10.2210/pdb3h9o/pdb
• 分子名称: 3-phosphoinositide-dependent protein kinase 1, 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine (3 entities in total)
• 機能のキーワード: pdk-1, kinase, protein structure, x-ray crysatllography, alternative splicing, atp-binding, cytoplasm, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O15530
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35947.16

構造登録者

Olland, A.M. (登録日: 2009-04-30, 公開日: 2009-08-25, 最終更新日: 2011-07-13)

• 主引用文献: Kim, K.H.,Wissner, A.,Floyd, M.B.,Fraser, H.L.,Wang, Y.D.,Dushin, R.G.,Hu, Y.,Olland, A.,Guo, B.,Arndt, K.; Benzo[c][2,7]naphthyridines as inhibitors of PDK-1; Bioorg.Med.Chem.Lett., 19:5225-5228, 2009; PubMed: 19628388; DOI: 10.1016/j.bmcl.2009.07.007

実験手法

X-RAY DIFFRACTION (2.3 Å)