Crystal structure of Ube2g2 complxed with the G2BR domain of gp78 at 1.8-A resolution

Summary for 3H8K

Related3FSH 2CYX
DescriptorUbiquitin-conjugating enzyme E2 G2, Autocrine motility factor receptor, isoform 2 (3 entities in total)
Functional Keywordsalpha beta, all alpha, ligase, ubl conjugation pathway, endoplasmic reticulum, membrane, metal-binding, phosphoprotein, receptor, transmembrane, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Multi-pass membrane protein  Q9UKV5
Total number of polymer chains2
Total molecular weight22003.18
Kalathur, R.C.,Das, R.,Li, J.,Byrd, R.A.,Ji, X. (deposition date: 2009-04-29, release date: 2009-07-14, Last modification date: 2017-11-01)
Primary citation
Das, R.,Mariano, J.,Tsai, Y.C.,Kalathur, R.C.,Kostova, Z.,Li, J.,Tarasov, S.G.,McFeeters, R.L.,Altieri, A.S.,Ji, X.,Byrd, R.A.,Weissman, A.M.
Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.
Mol.Cell, 34:674-685, 2009
PubMed: 19560420 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2009.05.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24213 0.5% 0.6% 5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02