3H69

Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms complexed with endothall

3H69 の概要

• エントリーDOI: 10.2210/pdb3h69/pdb
• 関連するPDBエントリー: 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68
• 分子名称: Serine/threonine-protein phosphatase 5, ZINC ION, (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (4 entities in total)
• 機能のキーワード: metalloenzyme, phosphatase, inhibitors, drug design, cytoplasm, hydrolase, iron, manganese, metal-binding, nucleus, protein phosphatase, tpr repeat
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P53041
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72535.55

構造登録者

Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. (登録日: 2009-04-23, 公開日: 2009-09-29, 最終更新日: 2023-11-01)

• 主引用文献: Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E.; Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin; J.Med.Chem., 52:4838-4843, 2009; PubMed: 19601647; DOI: 10.1021/jm900610k

実験手法

X-RAY DIFFRACTION (2.1 Å)