3H69
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms complexed with endothall
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | ENL0 |
| A | ASP271 |
| A | ASN303 |
| A | HIS352 |
| A | HIS427 |
| A | ZN501 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | ASP271 |
| A | ZN500 |
| A | ENL0 |
| A | ASP242 |
| A | HIS244 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ENL A 0 |
| Chain | Residue |
| A | ASP242 |
| A | HIS244 |
| A | ASP271 |
| A | ARG275 |
| A | ASN303 |
| A | HIS304 |
| A | HIS352 |
| A | ARG400 |
| A | HIS427 |
| A | GLU428 |
| A | PHE446 |
| A | TYR451 |
| A | ZN500 |
| A | ZN501 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 500 |
| Chain | Residue |
| D | ENL0 |
| D | ASP271 |
| D | ASN303 |
| D | HIS352 |
| D | HIS427 |
| D | ZN501 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 501 |
| Chain | Residue |
| D | ENL0 |
| D | ASP242 |
| D | HIS244 |
| D | ASP271 |
| D | ZN500 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ENL D 0 |
| Chain | Residue |
| D | ASP242 |
| D | HIS244 |
| D | ASP271 |
| D | ARG275 |
| D | ASN303 |
| D | HIS304 |
| D | ARG400 |
| D | HIS427 |
| D | GLU428 |
| D | VAL429 |
| D | PHE446 |
| D | TYR451 |
| D | ZN500 |
| D | ZN501 |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU300-GLU305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15577939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19601647","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H64","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aui |
| Chain | Residue | Details |
| A | HIS304 | |
| A | ASP274 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aui |
| Chain | Residue | Details |
| D | HIS304 | |
| D | ASP274 |
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 472 |
| Chain | Residue | Details |
| A | ASP242 | metal ligand |
| A | HIS427 | activator, metal ligand |
| A | HIS244 | metal ligand |
| A | ASP271 | metal ligand |
| A | ASP274 | activator, proton donor |
| A | ARG275 | transition state stabiliser |
| A | ASN303 | metal ligand, transition state stabiliser |
| A | HIS304 | proton acceptor, proton donor, proton relay |
| A | HIS352 | metal ligand |
| A | ARG400 | transition state stabiliser |
| site_id | MCSA2 |
| Number of Residues | 10 |
| Details | M-CSA 472 |
| Chain | Residue | Details |
