3H64
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with endothall
Summary for 3H64
Entry DOI | 10.2210/pdb3h64/pdb |
Related | 3H60 3H61 3H62 3H63 3H66 3H67 3H68 3H69 |
Descriptor | Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (4 entities in total) |
Functional Keywords | metalloenzyme, phosphatase, inhibitors, drug design, cytoplasm, hydrolase, iron, manganese, metal-binding, nucleus, protein phosphatase, tpr repeat |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P53041 |
Total number of polymer chains | 2 |
Total formula weight | 72493.67 |
Authors | Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. (deposition date: 2009-04-23, release date: 2009-09-29, Last modification date: 2023-11-01) |
Primary citation | Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52:4838-4843, 2009 Cited by PubMed: 19601647DOI: 10.1021/jm900610k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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