3H21

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

3H21 の概要

• エントリーDOI: 10.2210/pdb3h21/pdb
• 関連するPDBエントリー: 1TWS 1TWW 1TWZ 1TX0 1TX2 3H22 3H23 3H24 3H26 3H2A 3H2C 3H2E 3H2F 3H2M 3H2N 3H2O
• 分子名称: Dihydropteroate synthase, (2R)-2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: anthracis, folate biosynthesis, dihydropteroate, pterine, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Bacillus anthracis str. A2012
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66874.30

構造登録者

Yun, M.-K.,White, S.W. (登録日: 2009-04-14, 公開日: 2009-12-08, 最終更新日: 2023-09-06)

• 主引用文献: Hevener, K.E.,Yun, M.K.,Qi, J.,Kerr, I.D.,Babaoglu, K.,Hurdle, J.G.,Balakrishna, K.,White, S.W.,Lee, R.E.; Structural studies of pterin-based inhibitors of dihydropteroate synthase.; J.Med.Chem., 53:166-177, 2010; PubMed: 19899766; DOI: 10.1021/jm900861d

実験手法

X-RAY DIFFRACTION (2.32 Å)