3H21

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Summary for 3H21

Entry DOI	10.2210/pdb3h21/pdb
Related	1TWS 1TWW 1TWZ 1TX0 1TX2 3H22 3H23 3H24 3H26 3H2A 3H2C 3H2E 3H2F 3H2M 3H2N 3H2O
Descriptor	Dihydropteroate synthase, (2R)-2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	anthracis, folate biosynthesis, dihydropteroate, pterine, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bacillus anthracis str. A2012
Total number of polymer chains	2
Total formula weight	66874.30
Authors	Yun, M.-K.,White, S.W. (deposition date: 2009-04-14, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citation	Hevener, K.E.,Yun, M.K.,Qi, J.,Kerr, I.D.,Babaoglu, K.,Hurdle, J.G.,Balakrishna, K.,White, S.W.,Lee, R.E. Structural studies of pterin-based inhibitors of dihydropteroate synthase. J.Med.Chem., 53:166-177, 2010 Cited by PubMed: 19899766 DOI: 10.1021/jm900861d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation