3H1V
Human glucokinase in complex with a synthetic activator
Summary for 3H1V
Entry DOI | 10.2210/pdb3h1v/pdb |
Descriptor | Glucokinase, alpha-D-glucopyranose, 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione, ... (5 entities in total) |
Functional Keywords | glucokinase, diabetes, allosteric activator, alternative splicing, atp-binding, diabetes mellitus, disease mutation, glycolysis, kinase, nucleotide-binding, polymorphism, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 51290.15 |
Authors | Kamata, K.,Takahashi, K. (deposition date: 2009-04-14, release date: 2009-10-06, Last modification date: 2024-03-20) |
Primary citation | Takahashi, K.,Hashimoto, N.,Nakama, C.,Kamata, K.,Sasaki, K.,Yoshimoto, R.,Ohyama, S.,Hosaka, H.,Maruki, H.,Nagata, Y.,Eiki, J.,Nishimura, T. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg.Med.Chem., 17:7042-7051, 2009 Cited by PubMed: 19736020DOI: 10.1016/j.bmc.2009.05.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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