3H0C

Crystal Structure of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor

3H0C の概要

• エントリーDOI: 10.2210/pdb3h0c/pdb
• 関連するPDBエントリー: 2BUA 2BUB 2BUC
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide, ... (4 entities in total)
• 機能のキーワード: complex (hydrolase-inhibitor), dpp-iv, diabetes mellitus, drug design, hydrolase, serine protease, aminopeptidase, glycoprotein, protease, signal-anchor, transmembrane, cell membrane, disulfide bond, membrane, secreted
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 171650.91

構造登録者

Nordhoff, S.,Cerezo-Galvez, S.,Deppe, H.,Hill, O.,Lopez-Canet, M.,Rummey, C.,Thiemann, M.,Matassa, V.G.,Edwards, P.J.,Feurer, A. (登録日: 2009-04-09, 公開日: 2009-06-09, 最終更新日: 2020-07-29)

• 主引用文献: Nordhoff, S.,Cerezo-Galvez, S.,Deppe, H.,Hill, O.,Lopez-Canet, M.,Rummey, C.,Thiemann, M.,Matassa, V.G.,Edwards, P.J.,Feurer, A.; Discovery of b-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV; To be Published,

実験手法

X-RAY DIFFRACTION (2.66 Å)