3H0C
Crystal Structure of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor
3H0C の概要
エントリーDOI | 10.2210/pdb3h0c/pdb |
関連するPDBエントリー | 2BUA 2BUB 2BUC |
分子名称 | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide, ... (4 entities in total) |
機能のキーワード | complex (hydrolase-inhibitor), dpp-iv, diabetes mellitus, drug design, hydrolase, serine protease, aminopeptidase, glycoprotein, protease, signal-anchor, transmembrane, cell membrane, disulfide bond, membrane, secreted |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 171650.91 |
構造登録者 | Nordhoff, S.,Cerezo-Galvez, S.,Deppe, H.,Hill, O.,Lopez-Canet, M.,Rummey, C.,Thiemann, M.,Matassa, V.G.,Edwards, P.J.,Feurer, A. (登録日: 2009-04-09, 公開日: 2009-06-09, 最終更新日: 2020-07-29) |
主引用文献 | Nordhoff, S.,Cerezo-Galvez, S.,Deppe, H.,Hill, O.,Lopez-Canet, M.,Rummey, C.,Thiemann, M.,Matassa, V.G.,Edwards, P.J.,Feurer, A. Discovery of b-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV To be Published, |
実験手法 | X-RAY DIFFRACTION (2.66 Å) |
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