3GZ9

Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist

3GZ9 の概要

• エントリーDOI: 10.2210/pdb3gz9/pdb
• 分子名称: Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside, (2,3-dimethyl-4-{[2-(prop-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}phenoxy)acetic acid, ... (4 entities in total)
• 機能のキーワード: ppar, ppar delta, transcription, nuclear receptor fold, transcription regulation, hormone, growth factor receptor, complex, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31487.54

構造登録者

Wang, Z.,Sudom, A.,Walker, N.P. (登録日: 2009-04-06, 公開日: 2009-06-30, 最終更新日: 2024-02-21)

• 主引用文献: Connors, R.V.,Wang, Z.,Harrison, M.,Zhang, A.,Wanska, M.,Hiscock, S.,Fox, B.,Dore, M.,Labelle, M.,Sudom, A.,Johnstone, S.,Liu, J.,Walker, N.P.,Chai, A.,Siegler, K.,Li, Y.,Coward, P.; Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.; Bioorg.Med.Chem.Lett., 19:3550-3554, 2009; PubMed: 19464171; DOI: 10.1016/j.bmcl.2009.04.151

実験手法

X-RAY DIFFRACTION (2 Å)