3GXZ

Crystal structure of cyanovirin-n complexed to oligomannose-9 (man-9)

Replaces:  1M5M

Summary for 3GXZ

• Entry DOI: 10.2210/pdb3gxz/pdb
• Related: 1M5J 1M5M 3GXY
• Descriptor: Cyanovirin-N, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose, ... (6 entities in total)
• Functional Keywords: cyanovirin-n, hiv-inactivating, domain-swapping, gp120, man-9, oligosaccharide, antiviral protein, disulfide bond, protein synthesis inhibitor
• Biological source: Nostoc ellipsosporum
• Total number of polymer chains: 2
• Total formula weight: 24663.88

Authors

Botos, I.,O'Keefe, B.R.,Shenoy, S.R.,Seeberger, P.H.,Boyd, M.R.,Wlodawer, A. (deposition date: 2009-04-03, release date: 2009-04-14, Last modification date: 2023-09-06)

• Primary citation: Botos, I.,O'Keefe, B.R.,Shenoy, S.R.,Cartner, L.K.,Ratner, D.M.,Seeberger, P.H.,Boyd, M.R.,Wlodawer, A.; Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides; J.Biol.Chem., 277:34336-34342, 2002; PubMed: 12110688; DOI: 10.1074/jbc.M205909200

Experimental method

X-RAY DIFFRACTION (2.5 Å)