3GXY

Crystal structure of cyanovirin-n complexed to a synthetic hexamannoside

Replaces:  1M5J

Summary for 3GXY

• Entry DOI: 10.2210/pdb3gxy/pdb
• Related: 1M5J 1M5M 3GXZ
• Descriptor: Cyanovirin-N, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-pentyl alpha-D-mannopyranoside, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (5 entities in total)
• Functional Keywords: cyanovirin-n, hiv-inactivating, domain-swapping, gp120, man-9, oligosaccharide, antiviral protein, disulfide bond, protein synthesis inhibitor
• Biological source: Nostoc ellipsosporum
• Total number of polymer chains: 2
• Total formula weight: 23424.92

Authors

Botos, I.,O'Keefe, B.R.,Shenoy, S.R.,Seeberger, P.H.,Boyd, M.R.,Wlodawer, A. (deposition date: 2009-04-03, release date: 2009-05-05, Last modification date: 2023-09-06)

• Primary citation: Botos, I.,O'Keefe, B.R.,Shenoy, S.R.,Cartner, L.K.,Ratner, D.M.,Seeberger, P.H.,Boyd, M.R.,Wlodawer, A.; Structures of the complexes of a potent anti-HIV protein cyanovirin-n and high mannose oligosaccharides; J.Biol.Chem., 277:34336-34342, 2002; PubMed: 12110688; DOI: 10.1074/jbc.M205909200

Experimental method

X-RAY DIFFRACTION (2.4 Å)