3GXT
Crystal structure of alpha-galactosidase A at pH 4.5 complexed with 1-deoxygalactonijirimycin
Summary for 3GXT
| Entry DOI | 10.2210/pdb3gxt/pdb |
| Related | 3GXN 3GXP |
| Related PRD ID | PRD_900112 |
| Descriptor | Alpha-galactosidase A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose, ... (9 entities in total) |
| Functional Keywords | hydrolase, disease mutation, disulfide bond, glycoprotein, glycosidase, lysosome, rna editing |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 94767.68 |
| Authors | Lieberman, R.L. (deposition date: 2009-04-02, release date: 2009-05-26, Last modification date: 2020-07-29) |
| Primary citation | Lieberman, R.L.,D'aquino, J.A.,Ringe, D.,Petsko, G.A. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry, 48:4816-4827, 2009 Cited by PubMed: 19374450DOI: 10.1021/bi9002265 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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