3GXL

ALK-5 kinase complex with GW857175

Summary for 3GXL

Entry DOI	10.2210/pdb3gxl/pdb
Related	3GXJ
Descriptor	TGF-beta receptor type-1, N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine (3 entities in total)
Functional Keywords	tgf-beta, alk5, kinase, inhibitor, quinazoline, aortic aneurysm, atp-binding, craniosynostosis, disease mutation, disulfide bond, glycoprotein, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, receptor, serine/threonine-protein kinase, transferase, transmembrane
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P36897
Total number of polymer chains	1
Total formula weight	35076.38
Authors	Smith, W.,Janson, C. (deposition date: 2009-04-02, release date: 2009-04-21, Last modification date: 2023-11-01)
Primary citation	Gellibert, F.,Fouchet, M.-H.,Nguyen, V.-L.,Wang, R.,Krysa, G.,de Gouville, A.-C.,Huet, S.,Dodic, N. Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors Bioorg.Med.Chem.Lett., 19:2277-2281, 2009 Cited by PubMed: 19285388 DOI: 10.1016/j.bmcl.2009.02.087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation