3GSQ

Crystal structure of the binary complex between HLA-A2 and HCMV NLV-M5S peptide variant

3GSQ の概要

• エントリーDOI: 10.2210/pdb3gsq/pdb
• 関連するPDBエントリー: 3GSN 3GSO 3GSR 3GSU 3GSV 3GSW 3GSX
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, HCMV pp65 fragment 495-503, variant M5S (NLVPSVATV), ... (4 entities in total)
• 機能のキーワード: hla, human cytomegalovirus, pp65, t cell receptor (tcr), immune response, public response, immunodominance, restrained response, host-virus interaction, membrane, mhc i, polymorphism, immunoglobulin domain, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44531.54

構造登録者

Reiser, J.-B.,Saulquin, X.,Gras, S.,Debeaupuis, E.,Echasserieau, K.,Kissenpfennig, A.,Legoux, F.,Chouquet, A.,Le Gorrec, M.,Machillot, P.,Neveu, B.,Thielens, N.,Malissen, B.,Bonneville, M.,Housset, D. (登録日: 2009-03-27, 公開日: 2009-08-04, 最終更新日: 2021-10-20)

• 主引用文献: Gras, S.,Saulquin, X.,Reiser, J.B.,Debeaupuis, E.,Echasserieau, K.,Kissenpfennig, A.,Legoux, F.,Chouquet, A.,Le Gorrec, M.,Machillot, P.,Neveu, B.,Thielens, N.,Malissen, B.,Bonneville, M.,Housset, D.; Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.; J.Immunol., 183:430-437, 2009; PubMed: 19542454; DOI: 10.4049/jimmunol.0900556

実験手法

X-RAY DIFFRACTION (2.12 Å)