3GRT
HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX
Summary for 3GRT
Entry DOI | 10.2210/pdb3grt/pdb |
Descriptor | GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID, ... (4 entities in total) |
Functional Keywords | oxidoreductase, flavoenzyme, mixed disulfide |
Biological source | Homo sapiens (human) |
Cellular location | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390 |
Total number of polymer chains | 1 |
Total formula weight | 51572.88 |
Authors | Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. (deposition date: 1997-02-12, release date: 1997-08-12, Last modification date: 2023-08-09) |
Primary citation | Stoll, V.S.,Simpson, S.J.,Krauth-Siegel, R.L.,Walsh, C.T.,Pai, E.F. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Biochemistry, 36:6437-6447, 1997 Cited by PubMed: 9174360DOI: 10.1021/bi963074p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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