3GR2

AmpC beta-lactamase in complex with Fragment-based Inhibitor

Summary for 3GR2

Entry DOI	10.2210/pdb3gr2/pdb
Related	3GQZ 3GRJ 3GSG 3GTC 3GV9 3GVB
Descriptor	Beta-lactamase, 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one (3 entities in total)
Functional Keywords	hydrolase, ampc, lactamase, fragment, antibiotic resistance, periplasm, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Cellular location	Periplasm: P00811
Total number of polymer chains	2
Total formula weight	79370.04
Authors	Teotico, D.T.,Shoichet, B.K. (deposition date: 2009-03-24, release date: 2009-04-14, Last modification date: 2023-09-06)
Primary citation	Teotico, D.G.,Babaoglu, K.,Rocklin, G.J.,Ferreira, R.S.,Giannetti, A.M.,Shoichet, B.K. Docking for fragment inhibitors of AmpC beta-lactamase Proc.Natl.Acad.Sci.USA, 106:7455-7460, 2009 Cited by PubMed: 19416920 DOI: 10.1073/pnas.0813029106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation