3GQI
Crystal Structure of activated receptor tyrosine kinase in complex with substrates
3GQI の概要
エントリーDOI | 10.2210/pdb3gqi/pdb |
関連するPDBエントリー | 3GQL |
分子名称 | Basic fibroblast growth factor receptor 1, Phospholipase C-gamma-1, DECAVANADATE, ... (6 entities in total) |
機能のキーワード | phosphorylated kinase, py-recognition, tandem sh2 domains, atp analog, atp-binding, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, hydrolase, lipid degradation, sh2 domain, sh3 domain, transducer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein: P11362 Cell projection, lamellipodium : P10686 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 65292.33 |
構造登録者 | Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J. (登録日: 2009-03-24, 公開日: 2009-08-18, 最終更新日: 2023-11-22) |
主引用文献 | Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J. The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell(Cambridge,Mass.), 138:514-524, 2009 Cited by PubMed: 19665973DOI: 10.1016/j.cell.2009.05.028 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
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