3GPJ

Crystal structure of the yeast 20S proteasome in complex with syringolin B

3GPJ の概要

• エントリーDOI: 10.2210/pdb3gpj/pdb
• 関連するPDBエントリー: 1ryp 2ZCY 3BDM 3GPT 3GPW
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• 機能のキーワード: proteasome, virulence, ubiquitin, cancer therapy, immunology, cytoplasm, hydrolase, nucleus, phosphoprotein, protease, threonine protease, isopeptide bond, ubl conjugation, zymogen
• 由来する生物種: Saccharomyces cerevisiae (yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 706188.69

構造登録者

Groll, M.,Huber, R.,Kaiser, M. (登録日: 2009-03-23, 公開日: 2009-06-02, 最終更新日: 2023-09-06)

• 主引用文献: Clerc, J.,Groll, M.,Illich, D.J.,Bachmann, A.S.,Huber, R.,Schellenberg, B.,Dudler, R.,Kaiser, M.; Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition; Proc.Natl.Acad.Sci.USA, 106:6507-6512, 2009; PubMed: 19359491; DOI: 10.1073/pnas.0901982106

実験手法

X-RAY DIFFRACTION (2.7 Å)