3GPG

Crystal structure of macro domain of Chikungunya virus

3GPG の概要

関連するPDBエントリー3GPO 3GPQ
分子名称Non-structural protein 3 (2 entities in total)
機能のキーワードmacro domain, x domain, chikungunya, alphavirus, virus, vizier. viral enzymes involved in replication, atp-binding, cell membrane, endosome, helicase, hydrolase, lipoprotein, lysosome, membrane, methyltransferase, mrna capping, mrna processing, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, palmitate, phosphoprotein, protease, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, viral protein
由来する生物種Chikungunya virus
細胞内の位置Non-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Protease nsP2: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) Q8JUX6
ポリマー鎖数4
分子量合計74540.49
構造登録者
Malet, H.,Jamal, S.,Coutard, B.,Canard, B. (登録日: 2009-03-23, 公開日: 2009-07-21, 最終更新日: 2011-07-13)
主引用文献
Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83:6534-6545, 2009
PubMed: 19386706 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.00189-09
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.65 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.201402.6%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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