3GOP

Crystal structure of the EGF receptor juxtamembrane and kinase domains

3GOP の概要

• エントリーDOI: 10.2210/pdb3gop/pdb
• 分子名称: Epidermal growth factor receptor (2 entities in total)
• 機能のキーワード: kinase, juxtamembrane, egfr, anti-oncogene, atp-binding, cell cycle, cell membrane, disease mutation, disulfide bond, glycoprotein, isopeptide bond, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41667.27

構造登録者

Choi, S.H.,Alvarado, D.,Moravcevic, K.,Lemmon, M.A. (登録日: 2009-03-19, 公開日: 2009-07-07, 最終更新日: 2023-09-06)

• 主引用文献: Red Brewer, M.,Choi, S.H.,Alvarado, D.,Moravcevic, K.,Pozzi, A.,Lemmon, M.A.,Carpenter, G.; The juxtamembrane region of the EGF receptor functions as an activation domain.; Mol.Cell, 34:641-651, 2009; PubMed: 19560417; DOI: 10.1016/j.molcel.2009.04.034

実験手法

X-RAY DIFFRACTION (2.8 Å)