3GL6

Crystal structure of JARID1A-PHD3 complexed with H3(1-9)K4me3 peptide

3GL6 の概要

• エントリーDOI: 10.2210/pdb3gl6/pdb
• 分子名称: Histone demethylase JARID1A, Histone H3, ZINC ION, ... (4 entities in total)
• 機能のキーワード: phd finger, h3(1-9)k4me3 peptide, leukemia, alternative splicing, chromatin regulator, developmental protein, dioxygenase, iron, metal-binding, nucleus, oxidoreductase, phosphoprotein, polymorphism, transcription, transcription regulation, zinc, zinc-finger, chromosomal protein, dna-binding, nucleosome core
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus, nucleolus: P29375
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7104.05

構造登録者

Wang, Z.,Song, J.,Patel, D.J. (登録日: 2009-03-11, 公開日: 2009-05-05, 最終更新日: 2011-07-13)

• 主引用文献: Wang, G.G.,Song, J.,Wang, Z.,Dormann, H.L.,Casadio, F.,Li, H.,Luo, J.L.,Patel, D.J.,Allis, C.D.; Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.; Nature, 459:847-851, 2009; PubMed: 19430464; DOI: 10.1038/nature08036

実験手法

X-RAY DIFFRACTION (1.9 Å)