3GKW

Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody

3GKW の概要

• エントリーDOI: 10.2210/pdb3gkw/pdb
• 分子名称: Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: immunoglobulin fold, displaced strictly conserved trp 103 following kabat numbering, immune system, antitumor protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48244.47

構造登録者

Talavera, A.,Friemann, R.,Martinez-Fleites, C.,Moreno, E.,Krengel, U. (登録日: 2009-03-11, 公開日: 2009-08-04, 最終更新日: 2023-11-01)

• 主引用文献: Talavera, A.,Friemann, R.,Gomez-Puerta, S.,Martinez-Fleites, C.,Garrido, G.,Rabasa, A.,Lopez-Requena, A.,Pupo, A.,Johansen, R.F.,Sanchez, O.,Krengel, U.,Moreno, E.; Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation; Cancer Res., 69:5851-5859, 2009; PubMed: 19584289; DOI: 10.1158/0008-5472.CAN-08-4518

実験手法

X-RAY DIFFRACTION (2.5 Å)