3GJW

PARP complexed with A968427

Summary for 3GJW

Entry DOI	10.2210/pdb3gjw/pdb
Related	2RCW 2RD6 3GJW
Descriptor	Poly [ADP-ribose] polymerase 1, 7-(pyrrolidin-1-ylmethyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one (3 entities in total)
Functional Keywords	protein-inhibitor complex, acetylation, adp-ribosylation, dna damage, dna repair, dna-binding, glycosyltransferase, metal-binding, nad, nucleus, phosphoprotein, polymorphism, transferase, zinc, zinc-finger
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39436.14
Authors	Park, C.H. (deposition date: 2009-03-09, release date: 2010-03-09, Last modification date: 2023-09-06)
Primary citation	Miyashiro, J.,Woods, K.W.,Park, C.H.,Liu, X.,Shi, Y.,Johnson, E.F.,Bouska, J.J.,Olson, A.M.,Luo, Y.,Fry, E.H.,Giranda, V.L.,Penning, T.D. Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) Bioorg.Med.Chem.Lett., 19:4050-4054, 2009 Cited by PubMed: 19553114 DOI: 10.1016/j.bmcl.2009.06.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation