3GID

The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) in complex with Soraphen A

3GID の概要

• エントリーDOI: 10.2210/pdb3gid/pdb
• 分子名称: Acetyl-CoA carboxylase 2, SORAPHEN A (3 entities in total)
• 機能のキーワード: atp binding, carboxylase, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, manganese, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion : O00763
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121227.21

構造登録者

Price, A.,Kulathila, R. (登録日: 2009-03-05, 公開日: 2009-03-17, 最終更新日: 2024-02-21)

• 主引用文献: Raymer, B.,Kavana, M.,Price, A.,Wang, B.,Corcoran, L.,Kulathila, R.,Groarke, J.,Mann, T.; Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.; Bioorg.Med.Chem.Lett., 19:2804-2807, 2009; PubMed: 19359168; DOI: 10.1016/j.bmcl.2009.03.107

実験手法

X-RAY DIFFRACTION (2.3 Å)