3GI6

Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease

3GI6 の概要

• エントリーDOI: 10.2210/pdb3gi6/pdb
• 関連するPDBエントリー: 3GI5 3GI6
• 分子名称: Protease, (5S)-N-[(1S,2R)-2-Hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]-2-oxo-3-[3-(trif luoromethyl)phenyl]-5-oxazolidinecarboxamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: drug design, protease inhibitors, hiv-1 protease, aspartyl protease, hydrolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22580.20

構造登録者

Nalam, M.N.L.,Schiffer, C.A. (登録日: 2009-03-05, 公開日: 2010-03-09, 最終更新日: 2024-02-21)

• 主引用文献: Nalam, M.N.,Ali, A.,Altman, M.D.,Reddy, G.S.,Chellappan, S.,Kairys, V.,Ozen, A.,Cao, H.,Gilson, M.K.,Tidor, B.,Rana, T.M.,Schiffer, C.A.; Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.; J.Virol., 84:5368-5378, 2010; PubMed: 20237088; DOI: 10.1128/JVI.02531-09

実験手法

X-RAY DIFFRACTION (1.84 Å)