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3GI5

Crystal structure of protease inhibitor, KB62 in complex with wild type HIV-1 protease

Summary for 3GI5
Entry DOI10.2210/pdb3gi5/pdb
Related3GI4 3GI6
DescriptorProtease, (5S)-3-(3-Acetylphenyl)-N-[(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)pr opyl]-2-oxo-5-oxazolidinecarboxamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordsdrug design, protease inhibitors, hiv-1 protease, aspartyl protease, hydrolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22378.28
Authors
Nalam, M.N.L.,Schiffer, C.A. (deposition date: 2009-03-05, release date: 2010-03-09, Last modification date: 2024-02-21)
Primary citationNalam, M.N.,Ali, A.,Altman, M.D.,Reddy, G.S.,Chellappan, S.,Kairys, V.,Ozen, A.,Cao, H.,Gilson, M.K.,Tidor, B.,Rana, T.M.,Schiffer, C.A.
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
J.Virol., 84:5368-5378, 2010
Cited by
PubMed: 20237088
DOI: 10.1128/JVI.02531-09
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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