3GI6
Crystal structure of protease inhibitor, AD78 in complex with wild type HIV-1 protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10815.8 | 2 | UniProt (O38732) Pfam (PF00077) UniProt (by SIFTS) (P03369) | Human immunodeficiency virus 1 | |
| 2 | C (A) | (5S)-N-[(1S,2R)-2-Hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]-2-oxo-3-[3-(trif luoromethyl)phenyl]-5-oxazolidinecarboxamide | non-polymer | 663.7 | 1 | Chemie (D78) | |||
| 3 | D, E, F (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: O38732)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21631.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 948.6 | |
| All* | Total formula weight | 22580.2 |
