3GGU
HIV PR drug resistant patient's variant in complex with darunavir
Summary for 3GGU
Entry DOI | 10.2210/pdb3ggu/pdb |
Related | 3GGT |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total) |
Functional Keywords | darunvir, resistance, mutation score, hiv protease, tmc-114, hydrolase |
Biological source | Human immunodeficiency virus type 1 (BRU ISOLATE) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22455.06 |
Authors | Saskova, K.G.,Brynda, J.,Rezacova, P. (deposition date: 2009-03-02, release date: 2009-08-11, Last modification date: 2023-09-06) |
Primary citation | Saskova, K.G.,Kozisek, M.,Rezacova, P.,Brynda, J.,Yashina, T.,Kagan, R.M.,Konvalinka, J. Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir. J.Virol., 83:8810-8818, 2009 Cited by PubMed: 19535439DOI: 10.1128/JVI.00451-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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