3GGU

HIV PR drug resistant patient's variant in complex with darunavir

3GGU の概要

• エントリーDOI: 10.2210/pdb3ggu/pdb
• 関連するPDBエントリー: 3GGT
• 分子名称: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• 機能のキーワード: darunvir, resistance, mutation score, hiv protease, tmc-114, hydrolase
• 由来する生物種: Human immunodeficiency virus type 1 (BRU ISOLATE)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22455.06

構造登録者

Saskova, K.G.,Brynda, J.,Rezacova, P. (登録日: 2009-03-02, 公開日: 2009-08-11, 最終更新日: 2023-09-06)

• 主引用文献: Saskova, K.G.,Kozisek, M.,Rezacova, P.,Brynda, J.,Yashina, T.,Kagan, R.M.,Konvalinka, J.; Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir.; J.Virol., 83:8810-8818, 2009; PubMed: 19535439; DOI: 10.1128/JVI.00451-09

実験手法

X-RAY DIFFRACTION (1.8 Å)