3GGS

Human purine nucleoside phosphorylase double mutant E201Q,N243D complexed with 2-fluoro-2'-deoxyadenosine

3GGS の概要

• エントリーDOI: 10.2210/pdb3ggs/pdb
• 関連するPDBエントリー: 3GB9
• 分子名称: Purine nucleoside phosphorylase, 5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: enzyme-prodrug complex, disease mutation, glycosyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton : P00491
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 107159.56

構造登録者

Sawaya, M.R.,Afshar, S. (登録日: 2009-03-02, 公開日: 2009-04-14, 最終更新日: 2023-09-06)

• 主引用文献: Afshar, S.,Sawaya, M.R.,Morrison, S.L.; Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.; Protein Sci., 18:1107-1114, 2009; PubMed: 19388075; DOI: 10.1002/pro.91

実験手法

X-RAY DIFFRACTION (2.52 Å)